In analyzing the issues of the Quranic humanities, two distinct approaches can be identified: first, a monodisciplinary and detail-oriented approach that examines each science separately, and second, a systematic interdisciplinary study that considers the complex and reciprocal relationships between different sciences and provides a more comprehensive explanation of concepts. The comprehensive and holistic approach, while providing a systematic and comprehensive analysis of Quranic concepts, reduces the legislative complexities resulting from frequent notes and exceptions in legal and legislative systems by accurately anticipating scientific and social needs. This descriptive-analytical research, with a systematic method and emphasizing the importance of a holistic approach in Quranic interdisciplinary studies, deeply analyzes the theoretical and practical evidence proving the necessity of this approach. The findings of the study indicate that the character of the Holy Quran in systematically and comprehensively confronting various phenomena, as well as the interpretative method of the Ahl al-Bayt (a.s.) as prominent interpreters of revelation, are the most important documents and foundations of this approach. In addition, the practical application of this approach is clearly visible in the works and opinions of contemporary Islamic thinkers such as Martyr Sadr, Imam Khomeini, and Ayatollah Javadi Amoli. The explanation of these arguments and evidence, on the one hand, provides a theoretical and solid support for researchers in this field, and on the other hand, provides a solid basis for developing a systematic methodology in extracting, organizing, and applying Quranic humanities in various social arenas.